472（472+388）

Protein Gene Interaction Pubs Envelope surface glycoprotein gp160, precursor env PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia PubMed env Interactions between tumor suppressor protein PML, TopBP1 and ATM exhibit in HIV-1 Env-elicited syncytia 472 PubMed env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia 472 PubMed Rev rev Ataxia-telangiectasia-mutated (ATM) kinase enhances HIV-1 472 replication by stimulating the action of the HIV-1 Rev viral posttranscriptional regulator PubMed Tat tat HIV-1 Tat upregulates ATM expression in Tat-infected Jurkat T cells PubMed Vif vif A3G upregulates NKG2D ligands through an ATM pathway and in which HIV-1 Vif counteracts this upregulation by decreasing A3G expression PubMed Vpr vpr HIV-1 Vpr activates ATM, a DNA double-strand break kinase that is required for cell response to DNA damage and for genome stability PubMed integrase gag-pol DNA double-strand breaks enhance integration of HIV-1 into macrophages in an IN D64A mutant, which has defective integrase catalytic activity. This IN-D64A-independent viral transduction is blocked by an inhibitor of ATM PubMed gag-pol ATM is proposed to play a role in the prevention of HIV-1 Integrase mediated cell killing PubMed