dp1(dp1.2接口)

CNDP1, also known as glutamate carboxypeptidase-like dp1 protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease dp1 family. This protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine, and is identified as human carnosinase expressed in the brain. The CN1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protects dp1 against the adverse effects of high glucose levels on renal cells. In addition, this protein is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.? ?

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